In vitro characterization of the furin inhibitor MI-1851: Albumin binding, interaction with cytochrome P450 enzymes and cytotoxicityArticle Published on 2022-07-012023-07-09 Journal: Biomedicine & pharmacotherapy = Biomédecine & phar [Category] COVID19(2023년), [키워드] cell viability CYP3A4 furin inhibitor Human serum albumin MI-1851 primary human hepatocytes. [DOI] 10.1016/j.biopha.2022.113124 PMC 바로가기
A perspective on the applications of furin inhibitors for the treatment of SARS-CoV-2Article Published on 2022-04-012023-07-07 Journal: Pharmacological Reports [Category] COVID19(2023년), [키워드] furin inhibitor immune responses Non-peptide peptide SARS-CoV-2 spike protein. [DOI] 10.1007/s43440-021-00344-x PMC 바로가기
Identification of Kukoamine A, Zeaxanthin, and Clexane as New Furin InhibitorsArticle Published on 2022-03-032022-10-29 Journal: International Journal of Molecular Sciences [Category] COVID-19, MERS, SARS, [키워드] 293T addition assays Cancer carried Cell Clexane CMK Combination Compound compounds different diseases dose-dependent drug drugs in combination Effect Efficiency flow cytometry furin furin inhibitor furin inhibitors HEK cell identification identify infections inhibited inhibitor inhibitors New physiological protease Protein purified S protein S protein cleavage SARS-CoV-2 cell infection selected the SARS-CoV-2 therapeutic these compound viability Virtual screening Zeaxanthin [DOI] 10.3390/ijms23052796 PMC 바로가기 [Article Type] Article
Alpha-Soluble NSF Attachment Protein Prevents the Cleavage of the SARS-CoV-2 Spike Protein by Functioning as an Interferon-Upregulated Furin InhibitorResearch Article Published on 2022-01-112022-10-29 Journal: mBio [Category] COVID-19, COVID19(2023년), MERS, SARS, [키워드] addition alpha-soluble NSF attachment protein antiviral drug target attachment attachment protein cells cleavage COVID-19 Defense domain expression furin furin cleavage motif furin inhibitor Host increase inhibit interferon upregulated lack Loss NSF overexpression reduce Regulation SARS-COV-2 infection SARS-CoV-2 spike protein spike Spike protein the SARS-CoV-2 therapeutic option Therapeutic strategies transmission of SARS-CoV-2 Vesicle virulence virus virus infection [DOI] 10.1128/mbio.02443-21 PMC 바로가기 [Article Type] Research Article
D614G Substitution of SARS-CoV-2 Spike Protein Increases Syncytium Formation and Virus Titer via Enhanced Furin-Mediated Spike CleavageSARS-CoV-2 스파이크 단백질의 D614G 대체는 강화된 푸린 매개 스파이크 절단을 통해 융합체 형성 및 바이러스 역가를 증가시킵니다Research Article Published on 2021-07-272022-09-10 Journal: mBio [Category] MERS, SARS, 변종, 유전자 메커니즘, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 analyzed Cell cleavage coronavirus D614G D614G substitution enhanced enhancement expressing S protein Formation furin furin cleavage site furin inhibitor increase isolates mechanism Mutation Plaque assay promote Protein rapid expansion respiratory S protein S proteins SARS-CoV-2 SARS-CoV-2 strain SARS-CoV-2 strains severe acute respiratory syndrome Coronavirus significantly higher spike Substitution syncytium syncytium formation the S protein titer Transmissibility Treatment variant Viral viral isolate virus titer [DOI] 10.1128/mBio.00587-21 PMC 바로가기 [Article Type] Research Article
Furin cleavage of SARS-CoV-2 Spike promotes but is not essential for infection and cell-cell fusionSARS-CoV-2 스파이크의 푸린 절단은 감염 및 세포-세포 융합을 촉진하지만 필수적이지는 않습니다Research Article Published on 2021-01-252022-08-13 Journal: PLoS Pathogens [Category] COVID-19, Medicine and Health Sciences, [키워드] ACE2 ACE2 receptor activate activated acute respiratory syndrome coronavirus Amino acid Antiviral antiviral therapies attachment binding Cell cell-cell fusion cells cellular protease cellular proteases cleavage cleaved cocktail coronavirus COVID-19 pandemic CRISPR CRISPR-Cas9 Donor drug focus furin furin cleavage furin inhibitor furin inhibitors furin knockout cell furin knockout cells furin protease fusion fusion peptide host cell host cell membrane host cell receptor infect infected cell Infection inhibitor inhibitors motif multibasic site multinucleated cells mutant Mutation peptide pre-activation Prevent promote protease protease TMPRSS2 Protein reduce reduces required Research respiratory responsible reveal S protein S-mediated cell-cell fusion SARS-CoV-2 SARS-CoV-2 antiviral therapy SARS-COV-2 infection SARS-CoV-2 infections SARS-CoV-2 S SARS-CoV-2 S protein SARS-CoV-2 virus severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus 2 spike Spread syncytia formation target cell the S protein the SARS-CoV-2 thought TMPRSS2 TMPRSS2 protease treat triggered triggering unique Viral viral infection Viral protein viral spread virus virus entry virus entry process virus-host membrane fusion [DOI] 10.1371/journal.ppat.1009246 PMC 바로가기 [Article Type] Research Article
TMPRSS2 and furin are both essential for proteolytic activation of SARS-CoV-2 in human airway cellsResearch Article Published on 2020-07-232022-10-30 Journal: Life Science Alliance [Category] COVID-19, SARS, [키워드] activated Activation acute infection antiviral activity approach Calu-3 cathepsin Cell cells cleaved COVID-19 E64d equimolar furin furin inhibitor host cell proteases human airway cell human airway cells human airway epithelial inhibited inhibition knockdown not affect produced protease proteolytic activation provide respiratory tract S1/S2 site S2′ site SARS-CoV-2 SARS-CoV-2 replication SARS-CoV-2 S serine protease inhibitor severe disease Spike protein Spread Surface glycoprotein targets the S protein therapeutic potential TMPRSS2 TMPRSS2 expression TMPRSS2 inhibitor transmembrane serine protease Treatment virus entry virus replication [DOI] 10.26508/lsa.202000786 PMC 바로가기 [Article Type] Research Article